Symbiotes from space send an advanced hunting party to Earth to take out all of the superheroes; Spider-Man must team up with Marc Spector and Max Modell to save the planet.
When Toddler Groot lands on Earth to deliver an urgent warning, Spider-Man must decode the message and keep him out of the evil clutches of both A.I.M. and Baron Mordo.
When Spider-Man and Max Modell experiment on a sample of Venom symbiote, it escapes and unleashes a weapon of unknown purpose.
An insecure but courageous and intelligent teen named Peter Parker, a new student of Midtown High, is bitten by a radioactive spider and given powers. He becomes a hero named Spider-Man after the death of his uncle and he must adapt to this new way of life.